Vandy's average road performance last year was a 25 point loss. (That's including BIG blowout loss to Florida and 14-point win over Duke, but those pretty much average out.)
Vandy's average performance in season openers on the road is a 20-point loss (6 examples since 1990).
So based on Vandy's history, it doesn't seem outrageous.
On the other hand, in home openers we have won by an average of only 17 points since 1995, and only 9 points if you throw out Furman and the Citadel.
Of course, since we both have new coaches and all the other variables, it's pretty much a crap shoot anyway!