By "pro" I assume you mean the NFL and by college I assume you mean FBS . . . because otherwise your post makes no sense at all.
Here are the major differences today as I see them between the NFL and FBS.
1) The NFL teams have owners, and ALL of those owners are guaranteed a big. fat, profit every year -win or lose. FBS teams are "owned" by various colleges and universities and many (most?) of them actually lose money, while a few generate a nice profit for their owners.
2) The NFL has a hard salary cap which no owner is allowed to exceed, and a hard salary floor which all owners must exceed each year. FBS football teams have no kind of salary cap or salary floor at all. Some may choose to spend to the moon. Others may decide to cheap out over a paltry million dollars or two when hiring a coach.
3) The NFL has a central league office which oversees everything. It sets the schedules for all teams, negotiates TV rights deals in which all teams share equally, establishes objective rules for who gets into the playoffs and how they are seeded, has the ability to fine players (!!!) and teams for actions on the field. FCS football has nothing like this central league office. Teams set their own schedules, in coordination with their various conferences (of which there are many). The individual teams and their various conferences negotiate TV rights deals which vary wildly from team to team. Teams get into the playoffs based on the subjective whims of a self-appointed College Football Committee which is not even associated in any way with the NCAA . . . it is very much like Politburo. Neither it nor the NCAA has any authority to fine players or teams for actions on the field.
4) Because of 1, 2, and 3 above, every team in the NFL has a legitimate chance to compete for a championship wihin a perod of, say, three tro five years. Because of 1, 2, and 3 above, 90 percent of FBS teams have absolutely no realistic chance to compete for a championship over a period of decades.